Asymptomatic child heterozygous for hemoglobin S and hemoglobin Pôrto Alegre
نویسندگان
چکیده
منابع مشابه
An unusual case of heterozygous hemoglobin S/hemoglobin Fannin-Lubbock misidentified by capillary hemoglobin electrophoresis.
A 58-year-old Hispanic man under treatment for a gangrenous toe was found to have chronic microcytic anemia and a positive sickle cell screen. High-performance liquid chromatography and isoelectric focusing electrophoresis showed that the patient is double heterozygous for hemoglobin S and hemoglobin Fannin-Lubbock. The patient does not have any manifestations of a sickling disorder. Capillary ...
متن کاملHeterozygous Hemoglobin Sherwood Forest Causing Polycythemia
Hemoglobin (Hb) Sherwood Forest is a rare high-affinity hemoglobin first described in 1977, arising from an Arg to Thr substitution at codon 104 of the beta chain. This hemoglobin variant has been identified in few individuals and has been associated with a compensatory erythrocytosis in the homozygous state. Prior scarce case reports have noted that heterozygotes for this variant are phenotypi...
متن کاملLow proportions of glycosylated hemoglobin associated with hemoglobin S and hemoglobin C.
Using a cation-exchange chromatographic method, we found normal or subnormal values for glycosylated hemoglobin in a few diabetic patients with persistent hyperglycemia. Subsequent investigations revealed that these unexpected results had originated from black patients with diabetes. In view of common occurrence of abnormal hemoglobins in the Negro population, we subjected blood preparations to...
متن کاملAggregation of hemoglobin S and hemoglobin CHarlem with nonsickle hemoglobin in concentrated phosphate buffer.
The effect of HbA and HbF on both the aggregation and deaggregation of deoxy HbS and deoxy HbCHarlem in concentrated phosphate buffers was studied by a turbidimetric method. Although pure deoxy HbA is fully soluble in 2.4 M potassium phosphate buffer, the same concentration of deoxy HbAS was insoluble in the same buffer. Since there was little dissolved hemoglobin in the solute of a mixture of ...
متن کاملInfluence of Hemoglobin S Adducts on Hemoglobin A 2 Quantification
ical goal for imprecision (CV) was 13.6% [3]. Thus the performances of all of the methods may be satisfactory. However, as Fraser and Peterson have argued, even when biological variation, not analytical variation, is the limiting source of variation in a test, there is still great advantage in using a method with the least possible imprecision and bias [4]. The aca V was the least precise instr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Blood & Cancer
سال: 2010
ISSN: 1545-5009
DOI: 10.1002/pbc.22501